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What Can the Chemical Hold?

a review of the paper by Katherine Hendy on Academia.edu

by Brian Ballard Quass, the Drug War Philosopher

July 27, 2024



2025 update



Katherine Hendy's paper1 makes the important point that there is more than one way to evaluate the efficacy of psychoactive drugs such as MDMA and psilocybin. There is the chemical approach, which seeks to establish the efficacy of specific psychoactive substances in fighting officially recognized and discrete pathologies such as PTSD and so-called "treatment resistant depression." This approach uses clinical trials in which all participants have been scientifically identified as having one-and-the-same "illness" as defined by the DSM.

Then there is the efficacy as established by the positive transformation of the self, not by the alleviation of any one specific illness, but via an improvement in the individual's overall wellbeing and understanding of self. It is, of course, hoped that this understanding will resolve any specific psychological complaints (as for instance when one single afternoon of shroom use ended Paul Stamet's stuttering problem as a teenager2) -- but the treatment is considered to be efficacious provided only that it improves the self, and not merely if it manages to extirpate an isolated pathology belonging to that self. Participants in the latter therapy are all seen as people in need of a better understanding of self, rather than people who happen to all share a specific illness or psychological shortcoming that they wish to eliminate from their lives.

The author then explains why our choice of explanations matters when it comes to establishing drug efficacy. She makes the case that our government's reliance on chemical explanations of efficacy naturally leads to a kind of exception-riddled prohibition, one in which we outlaw all use of substances like MDMA and psilocybin except in cases where the "patient" or "user" has an officially recognized illness for which the drugs in question have been proven efficacious according to science's cramped definition of that term.

Why is science's definition of "efficacy" cramped? That is the question that Katherine does not ask in this paper but which, I believe, is at the very heart of the problem with modern substance prohibition.

In our purblind demand that a drug cure a specific illness, we are blind to the obvious general benefits of the drug that have been proven extant before our very eyes. The use of MDMA in the 1990s resulted in totally unprecedented peace and understanding between ethnic groups on the dance floors of London3. And yet this fact is never added to the plus side of any cost/benefit analyses about MDMA use that are undertaken by the scientists or their sometimes reluctant benefactors in government. Nor do they consider the costs of NOT legalizing the drug: the thousands of shock-rattled soldiers that will go without godsend treatments, the depressed who will suffer silently at home (perhaps while contemplating suicide), the anguished alcoholic who would gladly "switch vices" if only the FDA and the DEA would allow him or her to do so legally! And of course the use of psilocybin is seen in the same biased light. The time-honored positive use of psilocybin mushrooms by the Zapotec4 people of Oaxaca, Mexico, for instance, tells the government nothing, making it clear that the colonial viewpoint of Cortes himself is alive and well in 21st-century America, complete with its aggressive disdain for anti-scientific and/or anti-Christian healing practices.

In short, it is just a farce to say that the government even performs cost/benefit analyses when it comes to drug efficacy: they rather seek to find reasons to keep psychoactive substances as illegal as possible, only grudgingly approving them when scientists have jumped through all the necessary hoops - and jumped through them again and again - until some point at which the continued bullheadedness on the part of regulators becomes willful obstructionism even in the eyes of their own self-interested employees. This is why we have a National Institute for Drug Abuse rather than a National Institute for Drug Use. Our government is all about demonizing psychoactive substances.

This begs the question: Why are materialist scientists in charge of deciding what we should value in life? For that is exactly what they are doing when they sign off on the outlawing of prima facie godsends like MDMA and psilocybin. By ignoring all the huge and obvious benefits of such drugs, scientists are basically deciding for us that 100% safety is more important in life than universal brotherhood, and the prevention of school shootings, and the prevention of suicide, etc. - and surely such a conclusion is open to the liveliest of debates!

So until American scientists agree that "peace, love and understanding" is a good thing, they are obviously biased judges, determined to put today's "drugs" on show trials whose ultimate purpose is to prevent widespread use and to keep availability as problematic as possible for law-abiding Americans.

Conclusion: Scientists have no expertise in deciding what our priorities should be in life5. This is why mind-expanding drugs should be judged (if at all) by philosophers and humanists and empathic souls - not by materialists, for whom ecstatic visions of unity and love are considered mere "false creations proceeding from the heat-oppressed brain."

In some sense then, it does not matter whether we explain the efficacy of entheogens through chemical action alone or with regard to the ever-changing nature of the "self": as long as government officials follow the lead of science in refusing to recognize the glaringly obvious benefits of entheogens (and the equally obvious downsides of their prohibition - up to and including the creation of civil wars overseas), the attempted approval of godsends will always be met by bureaucratic foot dragging and specious complaints about obscure potential dangers, typically promoted by clinicians who are seeking to curry favor with the DEA, which needs drugs to be as illegal as possible in order for them to justify their multi-billion-dollar budget.

I write this by way of supplementing Hendry's paper, not to criticize it. The government's refusal to recognize the positive sides of the substances that they dismiss as "drugs" has never been sufficiently emphasized by anyone, to my knowledge, so she is scarcely alone in giving it short shrift.

I do, however, have one other consideration to add to this informative and well-researched paper.

Hendry claims that there are two ways of establishing drug efficacy: 1) via a chemical explanation and 2) via an explanation related to the "self." I believe that there is a third way, however. Remember, the "doors of perception"6 open outward, not inward. In Aldous Huxley's view, the efficacy of mescaline consisted in its ability to draw back the veil that shielded him from full-on reality. It did not directly teach him about his "self," but rather hinted at the immense and interconnected nature of the world of which he was a part, how every inch of it was glowing and pulsating with life. Huxley's experience led him to expand on the ideas of Henri Bergson7, that the mind is a reducing valve; its job is to limit our daily perceptions to what is potentially useful to us as human beings in contradistinction to showing us reality with a capital R. One thinks in this connection of the science of optics which tells us how the brain "fills in the blanks" caused by our species' poor peripheral vision with what are essentially mockups of what we apparently "should" be seeing in those poorly covered areas. Even if our periphery contains an orangutan riding a unicycle, we may not notice anything out of the ordinary there8.

Huxley's way of understanding the psychedelic experience has similarities to the beliefs of a Mesoamerican shaman, insofar as both see their drug-induced visions as being more real, in a sort of metaphysical way, than their everyday perceptions9. But the shaman would surely find the American emphasis on "self" as unhelpful at best, and selfish at worst, given the holistic philosophy of Cosmovision that is still prevalent among the indigenous peoples of Latin America. As human rights advocate Llona Suran explains:

"The Andean sensibility understands that every constitutive element of the Cosmos is intertwined, that every being is endowed with a spirit, whether it is mountains, rivers, trees, plants, or even rocks. It understands the world as a natural community of diverse and variable living communities, all of which, because of the bond that unites them, represent both their intrinsic value and the Whole."

-- "The Andean cosmovision as a philosophical foundation of the rights of nature" by Llona Suran10


So while I reject the materialist attempts to extract humanity from the world and treat one single isolated illness in a repeatable fashion (a la the chemical establishment of efficacy), I see the emphasis on "self" as problematic as well. It seems, in fact, to be a denial of the interconnectedness of Cosmovision as described above, an expression of the utilitarian 11 12 focus for which indigenous leaders all too justifiably reproach the West.

Personally, I do not need clinical trials to convince me that psilocybin is efficacious, however. The proof is extant after my first experience on the drug two weeks ago in Salem, Oregon. For despite materialist orthodoxy, the user is the expert when it comes to deciding the efficacy of psychoactive drugs, not some scientist working under the jaundiced eye of a cynical and skeptical DEA agent.

What was my experience?

The psilocybin "trip" vastly improved my mood and inspired me to take up entire new habits, including the writing of a daily diary for the first time in my life, and a handwritten diary at that! It motivated me to walk around Deerwood Mansion in Salem, Oregon, and create an introductory video for my Twitter followers, something that I would never have felt comfortable doing before psilocybin. In short, it worked, it worked, it worked!

But it also inspired frustration, because the idea that I cannot freely use mushrooms whenever I want for the purpose of improving my life like that is revolting to me. It represents the complete end of freedom - which I think is why so many people try not to even think about the War on Drugs. It's just asking for trouble. Who wants to realize that they are being stopped by their own government from living a full and productive life? It's America, after all. We're free, aren't we? No. It seems that "drugs" are so dangerous now that the government has a national security interest in thwarting our hopes and dreams. Who knew?

I remember feeling the same frustration when I was driving through the scrub grass in Arizona away from the Church of the Peyote Way six years ago after a peyote session that gave me bright-green visions of Mesoamerican imagery. Yes, the feeling was great, but I was pissed when I recalled that there were heartless people in Washington, D.C., who made a full-time job out of seeing to it that I experienced such eye-opening transcendence as little as possible in life, preferably zero times from their self-satisfied and undereducated point of view.

But back to that recent psilocybin journey of mine.

Though written for a very different purpose, the following lines from poet Percy Shelley capture the compelling spirit of my drug experience, one in which the world around me seemed immense and multiform and yet somehow inexorably one, a world of which I was but one small part -- indeed one almost unimaginably small part. And the vision was somehow therapeutic. For the time being at least, I felt like the world was my oyster, and I could not wait to get out in it and profit from that new understanding. But science, of course, is deaf to all anecdote. They need to see if taking psilocybin under controlled circumstances cures a specific condition, as in "hey, presto," as the Brits would say. If not, the materialist judges will simply shake their heads and cry: "Next!"... and thereby veto a world full of blatantly obvious benefits.


While the one Spirit's plastic stress
Sweeps through the dull dense world, compelling there
All new successions to the forms they wear;
Torturing th' unwilling dross that checks its flight
To its own likeness, as each mass may bear;
And bursting in its beauty and its might
From trees and beasts and men into the Heaven's light.





Author's Follow-up: February 2, 2025

picture of clock metaphorically suggesting a follow-up




In the above essay, I criticize the materialist approach to drug research. I failed to point out, however, that this approach is based on a specific philosophy or ideology, namely, that of behaviorism. In an attempt to turn psychology into a "real" science, the behaviorist holds that talk of human feelings and experience means nothing: that psychologists must devote their attention to quantifiable data alone13. It is this inhumane ideology that permits materialists to ignore the glaringly obvious benefits of drugs and to claim that they have no recognized uses. In this way, behaviorism gives a veneer of "science" to the DEA's absurd claim that drugs have no known benefits. The fact is that all mood-elevating drugs are potential antidepressants 14 -- the moment that we give empathic individuals the right to use them in a creative protocol. This is just psychological common sense and can only be denied by those who contend that anecdote does not matter, that history does not matter, and that psychological common sense does not matter.

Finally, a note about the Shelley poem, and specifically the opening line:

"While the one Spirit's plastic stress"...

The idea of a single pervasive "spirit" is not just poetry. The Kantian viewpoint, especially as interpreted by Schopenhauer, points to the existence of a timeless all-encompassing reality. This in turn comports with the experience of many users of psychedelics and phenethylamines. It is so common as to be a modern cliche that users of such substances report a sense of ontological oneness, a sense that reality is ultimately one, is ultimately interconnected.

Materialist scientists rule this possibility out a priori when they set to work studying such substances outside of all context and with regard only to the chemical effects of such drugs, as opposed to the reported experiences of the users -- which are all that matter in the real world, always assuming that the drugs in question are not biochemically toxic. The latter, by the way, is so rarely the case that it makes one wonder why the presumption is always that they are.


*materialism 15*


Notes:

1: What Can the Chemical Hold?: The Politics of Efficacy in the Psychedelic Renaissance Hendy, Katherine, Academia.edu, 2021 (up)
2: Fantastic Fungi: The Big-Screen Revival Tour Stamets, Paul (up)
3: How the Drug War killed Leah Betts DWP (up)
4: Peaceful Societies: Hallucinogens for the Zapotec Bonta, Bruce, UNC Greensboro, 2016 (up)
5: Why science is a joke in the age of the drug war DWP (up)
6: The Doors of Perception / Heaven and Hell Huxley, Aldous, Penguin Books, New York, 1970 (up)
7: Henri Bergson: French philosopher Britannica (up)
8: How the Brain Fills in the Blanks Gärdenfors Ph.D., Peter, Psychology Today, 2023 (up)
9: Andean cosmovision of the Kallawaya UNESCO (up)
10: The Andean cosmovision as a philosophical foundation of the rights of nature Suran, Ilona , Notre Affaire a Tous, 2021 (up)
11: Why John Stuart Mill is irrelevant to the drug debate DWP (up)
12: Drug Prohibition should be protested on principle, not on utilitarian grounds DWP (up)
13: How psychologists gaslight us about beneficial drug use DWP (up)
14: Antidepressants and the War on Drugs DWP (up)
15: How materialists lend a veneer of science to the lies of the drug warriors DWP (up)


Schopenhauer




Schopenhauer synthesizes the ideas of Immanuel Kant and Plato with the philosophy of eastern religions, according to which we human beings are unable to perceive Reality writ large. This limitation, however, which both Schopenhauer and Kant suggest applies to all human beings as such, may actually only apply to "sober" individuals, as William James was to point out a decade after Schopenhauer's death. James realized that the strategic use of drugs that provide self-transcendence can help one see past the so-called Veil of Maya. He went so far as to insist that philosophers must use such substances in an effort to understand ultimate realities -- advice that, alas, most modern philosophers seem committed to ignoring.

"No account of the universe in its totality," wrote James, "can be final which leaves these other forms of consciousness quite disregarded."

The exciting thing now is to consider Schopenhauer's philosophy in light of the revelations provided by certain drug use and to assess how such epiphanies tend to confirm, qualify or perhaps even refute the German pessimist's ideas about an eternal and unchangeable will, a will which the philosopher tells us is manifested in (or rather manifested AS) objects, animals, plants and persons. Schopenhauer tells us that the will corresponding to these entities is purposeful, for it seeks to create a specific kind of object or individual, but that the will is also meaningless, in the sense that the fact that it IS a specific kind of will is an arbitrary given, to which we need not ascribe any purpose, let alone a creator.

I am still trying to wrap my head around that latter claim, by the way, the idea that there can be teleology without design. I think I am slowly beginning to understand what Schopenhauer means by that claim in light of Kantian distinctions, but I am by no means sure that I agree with him. Yet I am not qualified to push back at this time. Further reading is required on my part before I can either refute him advisedly, or else concede his point. I do find, however, that Schopenhauer occasionally makes definitive-sounding claims that are actually quite open to obvious refutations.

In "The World as Will and Idea," for instance, he states that tropical birds have brilliant feathers "so that each male may find his female." Really? Then why are penguins not decked out with technicolor plumage? To assign "final causes" like this to nature is to turn animals into the inkblots of a biological Rorschach test. Not only is Schopenhauer being subjective here, but he has an agenda in making this particular kind of claim: he wants to underscore his belief that there is a logical causative explanation behind the fact that "wills" of the tropical birds would manifest in this colorful way, that it was not some act of extravagance on the part of a whimsical creator. But this kind of explanation is not the least bit compelling since one can imagine dozens of equally plausible "final causes" for the feature in question: the birds want to attract mates, the birds want to warn off predators, the birds want to mimic other yellow birds, the birds want to collectively camouflage themselves while roosting as one big yellow object (or more accurately, the birds' wills want to do these things).

One senses that Schopenhauer would respond as follows: "Fine. Give any reason you like, Ballard. But whatever you do, do not tell me that some suppositious God likes variety!"

And what about this famous pessimism? It's so typical of curmudgeons to try to make a universal law out of their own psychological issues. Schopenhauer does not seem to understand that attitude matters. As Hamlet said, "I could be bounded in a nutshell, and count myself a king of infinite space, were it not that I have bad dreams." It is neither the shortness of life nor the inhumanity of our fellows that ruins life for most people -- but rather their attitude TOWARD such circumstances. Every manic-depressive knows that a blue sky and party cake does not make a person happy, nor living amid postcard scenery. One can commit suicide in Disneyland just as well as Skid Row. It is attitude, attitude, attitude that matters -- from which it follows that it is a sin to outlaw substances that can help us adopt a positive attitude toward life. That's why it's so frustrating that philosophers like Schopenhauer pretend that life can be judged by circumstances alone. Only once we acknowledge that attitude matters can we clearly see the importance of the many mind-improving medicines of which Mother Nature is full, the meds that we slander today by classing them under the pejorative label of "drugs."








  • Ego Transcendence Made Easy
  • How the Drug War limits our understanding of Immanuel Kant
  • How the Drug War Outlaws Criticism of Immanuel Kant
  • Immanuel Kant on Drugs
  • Psilocybin Breakthrough
  • Schopenhauer and Drugs
  • Too Honest to Be Popular?
  • What Can the Chemical Hold?
  • What's Drugs Got to Do With It?
  • Drug War Propaganda from Hollywood
  • Ego Transcendence Made Easy
  • If this be reason, let us make the least of it!
  • Psilocybin Breakthrough
  • Schopenhauer and Drugs
  • Too Honest to Be Popular?
  • What Can the Chemical Hold?
  • What if Arthur Schopenhauer Had Used DMT?
  • What's Drugs Got to Do With It?





  • Ten Tweets

    against the hateful war on US




    Suicidal people should be given drugs that cheer them up immediately and whose use they can look forward to. The truth is, we would rather such people die than to give them such drugs, that's just how bamboozled we are by the war against drugs.

    We need a few brave folk to "act up" by shouting "It's the drug war!" whenever folks are discussing Mexican violence or inner city shootings. The media treat both topics as if the violence is inexplicable! We can't learn from mistakes if we're in denial.

    And where did politicians get the idea that irresponsible white American young people are the only stakeholders when it comes to the question of re-legalizing drugs??? There are hundreds of millions of other stakeholders: philosophers, pain patients, the depressed.

    Mayo Clinic is peddling junk. They are still promoting Venlafaxine, a drug that is harder to kick than heroin. The drug is only a problem, though, because of prohibition. It would be easy to get off of with the help of other drugs!!! WAKE UP, MAYO!

    This is the "Oprah fallacy," which has led to so much suffering. She told women they were fools if they accepted a drink from a man. That's crazy. If we are terrified by such a statistically improbable event, we should be absolutely horrified by horses and skateboards.

    Thanks to the Drug War, folks are forced to become amateur chemists to profit from DMT, a drug that occurs naturally in most living things. This is the same Drug War that is killing American young people wholesale by refusing to teach safe use and regulate drug supply.

    There are endless ways that psychoactive drugs could be creatively combined to combat addiction and a million other things. But the drug warrior says that we have to study each in isolation, and then only for treating one single board-certified condition.

    If the depressed patient laughs, that means nothing. Materialists have to see results under a microscopic or they will never sign off on a therapy.

    Kids should be taught beginning in grade school that prohibition is wrong.

    I'm told that science is completely unbiased today. I guess I'll have to go back and reassess my doubts about Santa Claus and the Tooth Fairy.


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